Related Experiment Video
Updated: Aug 6, 2026

A Mouse Model of Vascularized Heterotopic Spleen Transplantation for Studying Spleen Cell Biology and Transplant Immunity
Published on: June 11, 2019
Computed Tomography and Sonography of Spleen-related Complications in Sickle Cell Anemia
Sahil Gupta1, Adity Prakash1, Sudhansu Sekhar Mohanty1
1Department of Radio Diagnosis and Imaging, Kalinga Institute of Medical Sciences, KIIT Deemed to be University, Bhubaneswar, Odisha, India.
Background:
Spleen, being the filter of blood, is affected in virtually all cases of sickle cell anemia (SCA). Therefore, imaging features of the spleen can provide valuable inputs regarding the course and complications of SCA. To evaluate the diagnostic utility of ultrasonography and computed tomography (CT) in detecting splenic complications in patients with SCA.
Methods:
Seven patients with SCA underwent abdominal ultrasound and contrast-enhanced CT of the abdomen. The imaging features of their spleen are elucidated through this case series.
Results:
The imaging spectrum varied from splenomegaly, extramedullary hematopoiesis, infarcts, fibrosis, calcifications, splenic sequestration, secondary hemochromatosis, and splenic abscess to autosplenectomy.
Conclusions:
Imaging was able to diagnose spleen-related complications in SCA and added a valuable dimension to patient management.
Related Concept Videos
Computed Tomography
The technique was invented in the 1970s and is based on the principle that as X-rays pass through the body, they are absorbed or reflected at different levels. In the technique, a patient lies on a motorized platform while a computerized axial tomography (CAT) scanner rotates...
Imaging Studies for Cardiovascular System V: CT
Imaging Studies II: Positron Emission Tomography and Scintigraphy
Fundamental Principles of PET
Ultrasonography
During an ultrasonography procedure, a handheld device called a...
Imaging Studies III: Computed Tomography
Imaging Studies I: CT and MRI
Description of the Procedures
Computed Tomography (CT) scan:
Computed Tomography (CT) scans use X-ray technology to generate detailed images of bones, organs, and tissues. During the scan, the patient lies on a moving table...
