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Updated: Aug 6, 2026
11:39
The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
Published on: July 11, 2013
Cure for psoriasis - a prospective outlook
Siba P Raychaudhuri1, Smriti K Raychaudhuri2, Disha Chakraborty3
1Department of Medicine/Dermatology, VA Sacramento Medical Center, Northern California Health Care System, Mather, CA, United States; Department of Dermatology and Medicine/Division of Rheumatology, Allergy & Clinical Immunology, University of California School of Medicine, Davis, CA, United States.
Current Opinion in Immunology
|July 23, 2026
Summary
Psoriasis remission is redefined as long-term and drug-free. Targeting the interleukin-23 (IL-23)/IL-17 axis with early intervention, like IL-23 inhibitors, shows promise for durable remission.
Area of Science:
- Immunology
- Dermatology
- Translational Medicine
Background:
- Psoriasis, once incurable, is now viewed through the lens of sustained, drug-free remissions.
- The interleukin-23 (IL-23)/IL-17 axis and tissue-resident memory T cells (TRM) are central to psoriatic disease pathogenesis and recurrence.
Purpose of the Study:
- To re-evaluate the definition of 'cure' for psoriasis based on emerging remission data.
- To explore the efficacy of targeting the IL-23/IL-17 axis for achieving durable psoriasis remission.
- To investigate the role of early intervention in psoriatic disease management.
Main Methods:
- Analysis of clinical trial data (e.g., KNOCKOUT, GUIDE trials) evaluating IL-23 inhibitors.
- Assessment of TRM cell depletion as a biomarker for treatment response.
- Review of emerging curative strategies including stem cell therapy and gene editing.
Main Results:
- Intensified induction dosing of IL-23 inhibitors (e.g., risankizumab) led to significant TRM cell depletion and durable remission.
- Early intervention with IL-23 inhibitors (e.g., guselkumab) in early disease duration resulted in higher rates of complete skin clearance.
- Stem cell therapy and novel approaches like gene editing show potential for immune reprogramming and long-lasting remission.
Conclusions:
- A redefined 'cure' for psoriasis involves long-term, drug-free remission.
- Early targeting of the IL-23/IL-17 axis is critical for achieving sustained remission in psoriatic disease.
- Future psoriatic disease therapies may involve immune reprogramming through stem cell therapy and advanced interventions.
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