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Updated: Aug 6, 2026
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Anogenital Distance and Perineal Measurements of the Pelvic Organ Prolapse (POP) Quantification System
Published on: September 20, 2018
Association between first-trimester PAPP-A and large-for-gestational-age neonates in non-diabetic pregnancies: An
Turan Kaan Karakaya1, Hilmi Furkan Arslan2
1Department of Obstetrics and Gynaecology, Faculty of Medicine, Giresun University, Giresun, Turkey.
Summary
Elevated first-trimester pregnancy-associated plasma protein-A (PAPP-A) is linked to larger babies (LGA) in non-diabetic pregnancies. However, its low sensitivity limits its use as a standalone screening tool for fetal overgrowth.
Area of Science:
- Maternal-fetal medicine
- Reproductive endocrinology
Background:
- First-trimester screening plays a crucial role in predicting pregnancy outcomes.
- Pregnancy-associated plasma protein-A (PAPP-A) is a key biomarker in early pregnancy assessment.
Purpose of the Study:
- To assess the predictive capability of elevated first-trimester PAPP-A for large-for-gestational-age (LGA) neonates in non-diabetic pregnancies.
- To explore PAPP-A's potential interaction with known fetal growth factors.
Main Methods:
- Retrospective cohort study of 563 non-diabetic pregnancies.
- Stratification into high (>90th percentile) and normal PAPP-A groups.
- Multivariate logistic regression adjusted for confounders.
Main Results:
- High PAPP-A was associated with increased mean birth weight and a 2.4-fold higher incidence of LGA.
- PAPP-A levels positively correlated with neonatal length.
- Elevated PAPP-A demonstrated a high negative predictive value but low sensitivity and positive predictive value for LGA.
Conclusions:
- Elevated first-trimester PAPP-A is an independent predictor of fetal overgrowth in non-diabetic pregnancies.
- High PAPP-A may indicate increased insulin-like growth factor bioavailability.
- Clinical utility as a standalone screening tool is limited; further research in multiparametric models is warranted.
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