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A Comprehensive Review of the Current Systemic Medical Treatment Landscape for Vascular Malformations

Claire Fason1, Alexander J Jafari2,3,4, Adelaide A Hebert2,3,4,5

  • 1UTHealth McGovern Medical School, Houston, Texas, USA.

Pediatric Dermatology
|July 23, 2026
PubMed

Insights

Dermatologists manage vascular anomalies, classifying them as tumors or malformations. Advances in medical treatments like beta-blockers offer improved outcomes for vascular lesions, reducing surgical needs.

Area of Science:

  • Dermatology
  • Vascular Biology
  • Medical Therapeutics

Background:

  • Vascular anomalies are classified into tumors and malformations.
  • Hemangiomas are the most common vascular tumor with established treatments.
  • Vascular malformations require distinct therapeutic approaches.

Purpose of the Study:

  • To review current medical treatments for vascular anomalies.
  • To guide dermatologists in managing vascular malformations.
  • To highlight recent advances in therapy.

Main Methods:

  • Literature review of current medical management strategies.
  • Analysis of pharmacological and technological advancements.
  • Synthesis of treatment guidelines for vascular lesions.

Main Results:

  • Systemic and topical beta-blockers are standard for hemangioma treatment.
  • Medical therapies are increasingly replacing surgery for many vascular anomalies.
  • Recent advances improve patient outcomes and quality of life.

Conclusions:

  • Dermatologists are key in diagnosing and managing vascular anomalies.
  • Current medical treatments offer effective alternatives to surgery.
  • This review provides a guide to the evolving landscape of vascular malformation therapy.

Keywords:
PIK3CAalpelisibmiransertibovergrowth syndromessirolimussotorasibtrametinibvascular anomaliesvascular malformations

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