Related Experiment Video
Updated: Aug 6, 2026
10:09
Characterization of Immune Cell-derived Extracellular Vesicles and Studying Functional Impact on Cell Environment
Published on: June 2, 2020
Extracellular Vesicles and Cell Communication in Eukaryotic Microorganisms
Wanderley de Souza1,2, Emile S Barrias2,3
11Laboratório de Ultraestrutura Celular Hertha Meyer, Instituto de Biofísica Carlos Chagas Filho, Centro de Ciências da Saúde, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brasil;
Annual Review of Microbiology
|July 23, 2026
Summary
Extracellular vesicles (EVs) are cell-released particles crucial for intercellular communication. This review explores their role in host-pathogen interactions, particularly with eukaryotic microorganisms.
Area of Science:
- Cell Biology
- Immunology
- Parasitology
Background:
- Extracellular vesicles (EVs) are ubiquitous in biological systems, mediating intercellular communication.
- EVs carry diverse biomolecules (proteins, nucleic acids, lipids) influencing physiological and pathological processes.
- Their involvement in host-pathogen interactions is an emerging area of research.
Purpose of the Study:
- To review current knowledge on extracellular vesicles (EVs).
- To highlight the role of EVs in host-pathogen interactions, focusing on eukaryotic pathogens.
- To discuss new discoveries concerning EVs in host-pathogen systems.
Main Methods:
- Literature review of classical and recent studies on EVs.
- Analysis of EV biogenesis, content, and function.
- Examination of EV roles in eukaryotic pathogen-host interactions.
Main Results:
- EVs are key mediators of cellular communication, transporting biomolecules.
- EVs influence parasite behavior and host responses in pathogenic interactions.
- Diverse cell types produce EVs involved in host-pathogen dynamics.
Conclusions:
- Extracellular vesicles (EVs) are critical in host-pathogen interactions, affecting pathogenesis.
- Understanding EV-mediated communication offers insights into disease mechanisms.
- EVs hold potential as therapeutic agents and biomarkers in infectious diseases.
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