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A Package of Established Analytical Tools to Investigate the Solid-State Alteration of Lipid-Based Excipients
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Probing the moisture-induced drug recrystallization in hydroxypropyl methylcellulose-based amorphous solid

Arvindh Seshadri Suresh1, Famke Van Brempt2, Susanna Abrahmsén-Alami3

  • 1Department of Chemistry and Chemical Engineering, Chalmers University of Technology, 41296, Gothenburg, Sweden; FibRe Centre for Lignocellulose-based Thermoplastics, Department of Chemistry and Chemical Engineering, Chalmers University of Technology, SE-41296, Gothenburg, Sweden.

Carbohydrate Polymers
|July 23, 2026
PubMed
Summary

Hydroxypropyl methylcellulose (HPMC) in amorphous solid dispersions (ASDs) can lead to drug recrystallization when exposed to high humidity. Moisture absorption by HPMC drives this instability, particularly at the surface of the ASD.

Keywords:
Amorphous solid dispersionsDrug recrystallizationHot melt extrusionHydroxypropyl methylcelluloseNaproxenWater sorption

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