Related Experiment Video
Updated: Aug 6, 2026
03:23
Three-Dimensional Cell Culture Models to Investigate the Epithelial Barrier in Eosinophilic Esophagitis
Published on: May 10, 2024
Eosinophilic gastrointestinal diseases
Marco Vincenzo Lenti1,2, Carlo Maria Rossi3, Evan S Dellon4,5
1Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy. marco.lenti@unipv.it.
Nature Reviews. Disease Primers
|July 23, 2026
Summary
Eosinophilic gastrointestinal diseases (EGID) involve eosinophil buildup in the gut, causing various symptoms. While treatments for eosinophilic oesophagitis (EoE) are advancing, options for other EGID forms remain limited.
Area of Science:
- Gastroenterology
- Immunology
- Allergy
Background:
- Eosinophilic gastrointestinal diseases (EGID) are defined by eosinophilic inflammation in the GI tract without secondary causes.
- EGID encompasses eosinophilic oesophagitis (EoE), gastritis, enteritis, and colitis, individually or combined.
- The global incidence of EGID is rising, with EoE being the most prevalent form.
Purpose of the Study:
- To review the characteristics, pathogenesis, diagnosis, and treatment of EGID.
- To highlight the increasing prevalence and associated conditions of EGID.
- To discuss current and emerging therapeutic strategies for EGID.
Main Methods:
- Literature review of EGID pathogenesis, diagnosis, and treatment.
- Analysis of epidemiological data on EGID incidence and prevalence.
- Synthesis of information on clinical manifestations and patient quality of life.
Main Results:
- EGID pathogenesis involves T helper 2 cell responses and epithelial barrier disruption, often linked to other allergic disorders.
- Diagnosis relies on histology showing eosinophil infiltration after excluding secondary causes.
- Biologic therapies are available for EoE, but treatment options for other EGID subtypes are limited.
Conclusions:
- EGID represents a growing group of disorders with significant impact on patient quality of life.
- Further research is needed to develop effective treatments for non-EoE forms of EGID.
- Understanding the interplay between allergens and mucosal immunity is crucial for EGID management.
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