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Updated: Aug 6, 2026
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TBase - an Integrated Electronic Health Record and Research Database for Kidney Transplant Recipients
Published on: April 13, 2021
A Pharmaco-Epidemiological Research Program Leveraging a Nationwide Database of Kidney Transplantation
Pierre Marquet1,2, Antoine Humeau1, Sabrina Crépin1,2
1Pharmacology & Transplantation, Université de Limoges, UMR1248 INSERM, Limoges, France.
Pharmacoepidemiology and Drug Safety
|July 24, 2026
Summary
This study establishes a comprehensive kidney transplant database to analyze immunosuppressive drug effectiveness and patient outcomes. It will enable personalized medicine through advanced data analysis and predictive modeling for improved graft survival.
Area of Science:
- Nephrology
- Pharmacology
- Data Science
Background:
- Kidney transplantation outcomes are influenced by maintenance immunosuppressive drugs (MISDs).
- Optimal MISD strategies require evaluation beyond comparative randomized clinical trials.
- Individualized patient data is crucial for understanding drug efficacy and safety.
Purpose of the Study:
- To evaluate model-informed precision dosing of MISDs on graft and patient survival.
- To investigate long-term exposure-effects relationships and benefit-harm balance of MISD combinations.
- To develop a deep learning model for predicting renal graft function decline and individualizing MISD therapy.
Main Methods:
- Creation of the nationwide Pharmaco-Epidemiological Research Program in Kidney Transplantation (PERP-KT) dataset by linking national databases.
- Utilizing de-identified data extracts with regulatory and ethical approvals.
- Hosting the secure PERP-KT dataset within the French Health Data Hub.
Main Results:
- The CRISTAL registry includes data from 49,886 kidney donors and 47,842 recipients (2005-2020).
- CRISTAL data successfully linked to the French national Health Data System (SNDS) for 30,782 recipients.
- Pharmacological data linked via ISBA for 17,700 grafts and 17,576 recipients.
Conclusions:
- The PERP-KT database enables over 20 pharmaco-epidemiological studies.
- Extensive follow-up, large population size, and rich data support advanced analyses.
- The database provides a platform for personalized medicine in kidney transplantation.
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