Case Report: Multiple sclerosis and Neurofibromatosis type 1: a rare comorbidity
Angela Musci1, Luigi Bonan1, Eleonora Manzoni1
1Department of Biomedical and NeuroMotor Sciences (DIBINEM), University of Bologna, Bologna, Italy.
Frontiers in Neurology
|July 24, 2026
Summary
Neurofibromatosis type 1 (NF1) and Multiple Sclerosis (MS) rarely co-occur. Careful neuro-ophthalmological and neuroradiological evaluations are crucial for diagnosing this rare comorbidity due to overlapping symptoms.
Area of Science:
- Neurology
- Genetics
- Radiology
Background:
- Neurofibromatosis type 1 (NF1) and Multiple Sclerosis (MS) are distinct neurological disorders.
- Their co-occurrence is exceptionally rare, with fewer than 40 documented cases.
- Diagnostic challenges arise from overlapping clinical and neuroimaging features.
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