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Photodynamic Biomimetic Nanoparticles Accelerate Tumor Vascular Normalization Initiation
Yufei Liu1, Changheng Xie1, Yanfeng Huang1
1Jiangsu Key Laboratory of Druggability of Biopharmaceuticals Department of Pharmaceutics China Pharmaceutical University Nanjing China.
Exploration (Beijing, China)
|July 24, 2026
Summary
This study introduces IA@PM, a novel nanosystem that accelerates vascular normalization therapy (VNT) and enhances photodynamic therapy (PDT) for improved cancer treatment. This approach speeds up the therapeutic window, leading to better drug delivery and antitumor effects.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Oncology
Background:
- Abnormal tumor vasculature promotes tumor growth and hypoxia.
- Vascular normalization therapy (VNT) is effective but faces challenges due to delayed vascular normalization window (VNW) initiation.
Purpose of the Study:
- To develop a platelet-mimetic nanosystem (IA@PM) to accelerate VNW initiation and enhance cancer therapy.
- To investigate the synergistic effects of VNT and photodynamic therapy (PDT) using IA@PM.
Main Methods:
- Self-assembly of IA@PM using apatinib (APA), indocyanine green (ICG), and platelet membrane (PM).
- Utilizing PDT to balance pro- and anti-angiogenic factors and expedite VNW initiation.
- Evaluating accelerated VNW initiation for improved tumor drug delivery and antitumor efficacy.
Main Results:
- IA@PM significantly accelerated VNW initiation from day 4 to day 2 post-treatment.
- Enhanced tumor drug delivery was achieved due to expedited VNW initiation.
- A self-amplified therapeutic cycle between VNT and PDT resulted in significant antitumor effects.
Conclusions:
- IA@PM overcomes limitations in VNT by accelerating VNW initiation.
- The nanosystem enhances PDT efficacy with lower ICG doses, offering a novel strategy for cancer therapy.
