Related Experiment Video
Updated: Aug 8, 2026
07:22
A Standardized Procedure of Dressing Management for Toxic Epidermal Necrolysis
Published on: March 14, 2025
Recurrence after healing in pyoderma gangrenosum: a prospective registry-based cohort study
Jordan Gillespie1,2, Jaclyn Roland-McGowan1,2, Katelyn Downey1,2
1Oregon Health and Science University, Department of the School of Medicine, Portland, OR, USA.
Eclinicalmedicine
|July 24, 2026
Summary
Pyoderma gangrenosum recurred in 35% of patients, with risk remaining high five years post-healing. Peristomal location indicates higher recurrence, suggesting maintenance therapy may be needed.
Area of Science:
- Dermatology
- Immunology
- Clinical Medicine
Background:
- Pyoderma gangrenosum (PG) is a rare neutrophilic dermatosis.
- The real-world recurrence rate of PG after healing is unknown.
- Understanding recurrence patterns is crucial for clinical practice and research.
Purpose of the Study:
- To evaluate recurrence patterns of pyoderma gangrenosum.
- To inform clinical practice and future research on PG management.
Main Methods:
- A prospective registry of PG patients was utilized.
- Patients who healed were identified and categorized into healed or recurrent groups.
- Descriptive statistics, Kaplan-Meier methods, and Cox proportional hazards modeling were employed to analyze recurrence.
Main Results:
- Of 116 healed PG patients, 41 (35.3%) experienced recurrence.
- Cumulative recurrence risk was 27% at 1 year and 41.3% at 5 years.
- History of diabetes mellitus and ever-smoking showed nominal associations with recurrence.
Conclusions:
- Pyoderma gangrenosum recurrence affects approximately one-third of patients.
- Recurrence risk remains elevated long-term, especially for peristomal PG.
- Maintenance therapy may be necessary for specific patient groups post-healing.