Related Experiment Video

Updated: Aug 6, 2026

Integrated Photoacoustic, Ultrasound, and Angiographic Tomography (PAUSAT) for NonInvasive Whole-Brain Imaging of Ischemic Stroke
06:45

Integrated Photoacoustic, Ultrasound, and Angiographic Tomography (PAUSAT) for NonInvasive Whole-Brain Imaging of Ischemic Stroke

Published on: June 2, 2023

Correction: pH-sensitive probes for ischemic stroke: advancing early detection and accurate grading

Chen Zou1,2,3, Lijun Wang3, Yue Wu1,2,3

  • 1School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai, China.

Frontiers in Molecular Biosciences
|July 24, 2026
PubMed

Keywords:
early detectionischemic strokemetabolic imagingpH-based gradingpH-responsive nanoprobestissue acidosis

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An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...