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Beyond the Colon: Acute Hemolysis Associated With Etrasimod Therapy
Sohaib Ahmed1, Saud Khan2, Eric Vargas Carranza1
1Internal Medicine, University of Central Florida, Orlando, USA.
Cureus
|July 24, 2026
Summary
Etrasimod, an S1P receptor modulator for ulcerative colitis, may cause immune-mediated hemolytic anemia. This rare complication requires prompt diagnosis and treatment with corticosteroids for recovery.
Area of Science:
- Immunology
- Hematology
- Pharmacology
Background:
- Etrasimod is an oral sphingosine 1-phosphate (S1P) receptor modulator for ulcerative colitis (UC).
- The safety profile of etrasimod is established, but hematologic complications require further characterization.
- Ulcerative colitis treatment landscape and the role of S1P modulators.
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