Related Experiment Video

Updated: Aug 6, 2026

Sample Preparation for Mass Spectrometry-based Identification of RNA-binding Regions
10:52

Sample Preparation for Mass Spectrometry-based Identification of RNA-binding Regions

Published on: September 28, 2017

RNA-binding protein RBM47 in health and disease: molecular mechanisms, preclinical evidence, and translational

Shihua Huang1, Qingsong Wang2, Junhong Shen3

  • 1Department of Neurology, West China Hospital Sichuan University Jintang Hospital, Jintang First People's Hospital, Chengdu, Sichuan, China.

Frontiers in Immunology
|July 24, 2026
PubMed

Insights

RNA-binding motif protein 47 (RBM47) has dual roles in disease, acting as a tumor suppressor in some cancers and an oncogene in others. Further research is needed to explore its therapeutic potential.

Area of Science:

  • Molecular Biology
  • Cancer Research
  • Immunology

Background:

  • RNA-binding motif protein 47 (RBM47) is a conserved protein regulating RNA processing.
  • RBM47 influences C-to-U RNA editing, alternative splicing, and mRNA stability.
  • Its role in disease is context-dependent, showing both tumor-suppressive and oncogenic activities.

Purpose of the Study:

  • To review the molecular characteristics and pathological mechanisms of RBM47.
  • To discuss the potential of RBM47 as a biomarker and therapeutic target.
  • To analyze current limitations and translational challenges for RBM47 research.

Main Methods:

  • Literature review of preclinical studies.
  • Analysis of RBM47's involvement in various cancers (BC, CRC, RCC, PTC, NSCLC, glioma, PC).
  • Examination of RBM47's role in POCD, IBD, and innate immunity.

Main Results:

  • RBM47 suppresses tumors by inhibiting Wnt/β-catenin, PI3K-AKT, and Nrf2 pathways in several cancers.
  • RBM47 promotes oncogenesis in glioma and PC by enhancing M2 macrophage polarization and immune evasion.
  • Aberrant RBM47 expression is linked to POCD, IBD, and antiviral immunity in preclinical models.

Conclusions:

  • RBM47 exhibits context-specific dual roles in human diseases, acting as a tumor suppressor or oncogene.
  • RBM47 presents potential as a biomarker and therapeutic target, but clinical applications are preclinical.
  • Further research is crucial to overcome limitations and translational bottlenecks for RBM47-targeted therapies.
Keywords:
RBM47RNA-binding proteinsepithelial-mesenchymal transitionpost-transcriptional regulationprognostic biomarkertherapeutic targettumor microenvironment

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