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Multidisciplinary Treatment for Esophagogastric Junction Cancer From a Dutch Perspective
Hidde C G Overtoom1,2,3, Suzanne S Gisbertz1,2,3
1Department of Surgery, Amsterdam UMC Location University of Amsterdam Amsterdam the Netherlands.
Annals of Gastroenterological Surgery
|July 24, 2026
Summary
Esophagogastric junction cancer survival has improved in the Netherlands due to advancements in minimally invasive surgery and perioperative chemotherapy. Centralized care with multidisciplinary teams further enhances treatment quality and patient outcomes.
Area of Science:
- Gastroenterology
- Surgical Oncology
- Public Health
Background:
- Esophagogastric junction (EGJ) cancer presents a growing global health challenge.
- Recent years have seen significant progress in managing EGJ cancer, particularly in the Netherlands.
Purpose of the Study:
- To review advancements in EGJ cancer treatment and outcomes in the Netherlands.
- To highlight the impact of multimodal strategies, minimally invasive surgery, and centralized care.
Main Methods:
- Analysis of trends in perioperative treatment strategies, including systemic therapy (e.g., FLOT regimen).
- Evaluation of the adoption and outcomes of minimally invasive surgical techniques.
- Assessment of the role of care centralization and multidisciplinary teams, supported by registry data.
Main Results:
- Marked improvements in perioperative outcomes and overall survival for EGJ cancer patients.
- Increased adoption of minimally invasive transthoracic techniques leading to better radicality and reduced morbidity.
- Consistent association between centralized care, specialized multidisciplinary teams, and enhanced surgical quality and survival.
Conclusions:
- Multimodal treatment strategies, including perioperative chemotherapy and minimally invasive surgery, have significantly improved EGJ cancer care.
- Centralization of EGJ cancer care within specialized multidisciplinary teams is crucial for optimizing surgical quality and patient survival.
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