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A Quantitative Detection Method for MicroRNAs in the Kidney of an Ischemic Kidney Injury Mouse Model
Published on: September 11, 2020
EXPRESS: Circulating and Urinary microRNAs in Diabetic Kidney Disease: Stage and Sample-Specific Signatures with
Gangireddy Venkatratna Bharat1, Mohanram M1, Ria Murugesan2
1Department of General Medicine, SRM Medical College Hospital and Research Centre, Faculty of Medicine and Health Sciences, SRM Institute of Science and Technology, Kattankulathur, Chengalpattu, TN, India.
Summary
MicroRNAs (miRNAs) show potential as early biomarkers for diabetic kidney disease (DKD). Urinary miRNA124, miRNA21, and miRNA34a, along with circulating miRNA126 and miRNA192, may help track DKD progression.
Area of Science:
- Biomarkers
- Nephrology
- Molecular Biology
Background:
- Diabetic kidney disease (DKD) is a major cause of end-stage renal disease.
- Current biomarkers for DKD lack sensitivity, hindering early detection.
- MicroRNAs (miRNAs) are emerging as potential non-invasive biomarkers for DKD, but evidence is inconsistent.
Purpose of the Study:
- To systematically evaluate dysregulated miRNAs in DKD.
- To assess the association of miRNAs with clinical parameters across albuminuria stages.
- To identify promising miRNA biomarkers for DKD progression.
Main Methods:
- Systematic literature search of PubMed, Scopus, and Embase for DKD miRNA expression studies.
- Meta-analysis of standardized mean differences (SMDs) using random-effects models.
- Risk of bias assessment using the Newcastle-Ottawa Scale and correlation analyses.
Main Results:
- Urinary miRNA124 showed significant progressive upregulation across albuminuria stages (SMD > 2.04).
- Urinary and circulating miRNA21 demonstrated progressive upregulation.
- Circulating miRNA126 was consistently downregulated, and urinary miRNA192 was downregulated; circulating miRNA192 showed inconsistent expression.
- Urinary miRNA34a correlated positively with UACR and HbA1c; circulating miRNA21 and miRNA192 inversely correlated with albuminuria.
Conclusions:
- Urinary miRNA124, miRNA21, and miRNA34a are promising biomarkers for DKD.
- Circulating miRNA126 and miRNA192 also show potential as DKD biomarkers.
- Prospective validation studies are necessary to confirm the utility of these miRNAs in DKD management.
