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Engineering Injectable Co-Assembled Hyaluronic Acid-Based Hydrogel by Photothermal Driven Recombinant Human Type III
Yafang Chen1,2, Xue Zhan1,2, Zhenyu Luo3
1National Engineering Research Center for Biomaterials, Sichuan University, Chengdu, China.
Small (Weinheim an Der Bergstrasse, Germany)
|July 24, 2026
Summary
This study presents a novel injectable hydrogel for infected wound repair. The AHAMA+rhCM hydrogel effectively kills bacteria and promotes tissue regeneration under near-infrared light irradiation.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Nanotechnology
Background:
- Adhesive hydrogels with phototherapy show promise for infected tissue repair.
- Bacterial stress adaptation can reduce photothermal therapy efficacy.
Purpose of the Study:
- To develop an injectable hydrogel (AHAMA+rhCM) integrating aldehyde-functionalized hyaluronic acid and collagen-modified molybdenum disulfide.
- To evaluate its efficacy in infected wound healing via photothermal therapy.
Main Methods:
- Fabrication of a double-network hydrogel using AHAMA and rhCol III-modified MoS2.
- Assessment of mechanical properties, dispersion stability, and photothermal conversion.
- In vivo study on Staphylococcus aureus-infected wound healing models.
Main Results:
- AHAMA+rhCM hydrogel under NIR irradiation showed superior wound healing compared to controls.
- The hydrogel exhibited potent antibacterial activity, reduced inflammation, and promoted angiogenesis.
- Optimized collagen deposition and accelerated tissue regeneration were observed.
Conclusions:
- The photothermal-driven AHAMA+rhCM hydrogel is a promising strategy for infected wound repair.
- It offers dual action: effective antibacterial properties and enhanced tissue regeneration.
- This approach addresses bacterial stress adaptation challenges in photothermal therapy.
