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Age and Urinary Retention in Women After Botox Treatment for Overactive Bladder
Nicholas F Scioscia1, Preston Edge2, Sean Tackett3,4
1Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, MD.
Urogynecology (Philadelphia, Pa.)
|July 24, 2026
Summary
Older adults over 70 are not at increased risk for urinary retention after onabotulinumtoxinA treatment for overactive bladder. This study found no significant difference in catheterization needs or post-void residual volumes between age groups.
Area of Science:
- Urology
- Geriatrics
- Pharmacology
Background:
- Urinary retention is a known complication of intradetrusor onabotulinumtoxinA treatment.
- Data on whether older adults face a higher risk of urinary retention post-treatment are inconsistent.
Purpose of the Study:
- To determine if age over 70 is associated with an increased risk of urinary retention after intradetrusor onabotulinumtoxinA administration for overactive bladder.
Main Methods:
- Retrospective cohort study of women treated with intradetrusor onabotulinumtoxinA (2017-2022).
- Primary exposure: age >70 years at first treatment.
- Primary outcomes: need for catheterization and postvoid residual volume ≥200 mL.
Main Results:
- 347 women included; 52.2% were over 70.
- 8.1% required catheterization, with no significant difference between age groups (P=0.33).
- 23.4% had postvoid residual volume ≥200 mL, also not significantly different between age groups (P=0.98).
Conclusions:
- Age over 70 years is not a risk factor for developing urinary retention after intradetrusor onabotulinumtoxinA treatment.
- OnabotulinumtoxinA can be safely administered to older adults with overactive bladder without increased risk of urinary retention.
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