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Updated: Aug 6, 2026

In Vivo Electrophysiological Measurement of Compound Muscle Action Potential from the Forelimbs in Mouse Models of Motor Neuron Degeneration
06:35

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Published on: June 15, 2018

Late-Onset Rapidly Progressive Spastic Paraplegia with Extensive White Matter Abnormalities Associated with an MFN2

Jiwon Yang1, Hyeon-Mi Park1, Yeong-Bae Lee1

  • 1Department of Neurology, Gil Medical Center, Gachon University College of Medicine, Incheon 21565, Republic of Korea.

Neurosci
|July 24, 2026
PubMed
Summary

Mitofusin-2 (MFN2) gene variants can cause a rare, rapidly progressing form of spastic paraplegia. This case highlights MFN2 variants in patients with late-onset spasticity and brain white matter abnormalities.

Keywords:
Charcot–Marie–Tooth diseaseaxonalmitochondriaspastic paraplegiatype 2A1

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