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Advances in chrysin research for cardiovascular disorders: mechanistic insights and therapeutic prospects

Rudra Pratap Singh1, Ashutosh Solanki2

  • 1Department of Pharmacology, College of Pharmacy, JSS University, Noida, 201301, Uttar Pradesh, India.

Molecular Biology Reports
|July 24, 2026
PubMed

Insights

Chrysin, a natural flavonoid, offers cardioprotection against various heart conditions by reducing oxidative stress and inflammation. This review highlights its potential therapeutic mechanisms for cardiovascular disorders.

Area of Science:

  • Cardiovascular Research
  • Pharmacology
  • Natural Product Chemistry

Background:

  • Chrysin (5,7-dihydroxyflavone) is a flavonoid found in numerous dietary sources.
  • It exhibits potential cardioprotective effects in managing cardiovascular disorders.

Purpose of the Study:

  • To review the therapeutic potential of chrysin in various cardiovascular disorders.
  • To elucidate the cellular and molecular mechanisms of chrysin's cardioprotective effects.

Main Methods:

  • Literature review of research on chrysin and cardiovascular disorders.
  • Analysis of studies detailing chrysin's effects on oxidative stress, inflammation, endothelial function, and apoptosis.
  • Examination of signaling pathways modulated by chrysin.

Main Results:

  • Chrysin reduces oxidative stress by enhancing antioxidant enzymes (SOD, catalase, glutathione).
  • It exhibits anti-inflammatory effects by suppressing pro-inflammatory mediators (interleukins, NF-κB, TNF-α, COX-2).
  • Chrysin improves endothelial function, lipid profiles, and nitric oxide levels, while decreasing apoptosis.

Conclusions:

  • Chrysin demonstrates significant cardioprotective potential through multiple molecular mechanisms.
  • It modulates key signaling pathways (PI3K/Akt/Nrf2, MAPK, NOX4, TGF-β/Smad) relevant to cardiovascular health.
  • Further research into chrysin as a therapeutic agent for cardiovascular diseases is warranted.

Keywords:
ApoptosisCardiovascular disordersChrysinEndothelial dysfunctionInflammationOxidative stressPI3K/Akt/ Nrf2 signalling

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