A Framework for Predicting Neurofeedback Treatment Response in ADHD Using EEG Functional Connectivity and Genetic
Ziyue Li1, Zhinuan Zhu1,2, Dong Li1
1Department of Otolaryngology, The Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325027, Zhejiang, China.
Abstract:
In this article, we present a computational framework for predicting treatment response to neurofeedback (NF) among patients with Attention-Deficit/Hyperactivity Disorder (ADHD). The proposed framework uses functional brain connectivity analysis of electroencephalogram (EEG) signals acquired during an early-to-mid NF treatment window to classify participants as eventual responders or non-responders. The six-stage algorithm was evaluated using an open-access EEG dataset from the Mendeley Data repository comprising 60 children with ADHD aged 6-12 years. The framework includes a preprocessing pipeline designed to reduce EEG artifacts and noise. Next, spectral features, specifically of the alpha and beta frequency bands, were extracted from the noise-reduced signals. In the fourth stage, functional connectivity was estimated by calculating Phase Locking Value (PLV) between all electrode pairs, thereby quantifying inter-channel phase synchronization. The fifth stage, which is an essential stage, was dimensionality reduction to find the most discriminative features. Dimensionality reduction was achieved in a two-process manner; for the first process, statistical screening was performed using Welch's t-test with FDR correction, followed by GA-based channel selection to identify the most discriminative electrode subset. The GA analysis identified a compact six-channel subset consisting of C3, C4, Cz, Fz, Fp1, and T6 from the original 32-channel montage. In the last classification stage, the reduced feature vectors were input as part of an ensemble of machine learning classifiers to achieve classification. Model performance was evaluated using subject-wise grouped cross-validation, with the best configuration achieving an accuracy of 84.72%. These results suggest that the proposed data-driven framework may support future research on individualized NF response prediction, pending validation on independent clinical datasets.
