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Innovative Strategies for Organ Preservation in Heart Transplantation: Uniform Cooling Preservation and Ex-situ Normothermic Perfusion
Published on: November 28, 2025
2025 Update of Heart Transplant Landscape in France
Richard Dorent1, Naissa Bacar1, Guillaume Lebreton2
1Medical and Scientific Department, Agency of Biomedicine, Saint-Denis La Plaine, France.
Transplantation
|July 24, 2026
Summary
France
Area of Science:
- Cardiology
- Transplant Surgery
- Public Health
Background:
- Reviews the current state of heart transplantation in France.
- Focuses on donation, waitlist, and transplant rates.
- Examines waitlist and post-transplant outcomes.
Purpose of the Study:
- To provide a comprehensive overview of heart transplantation in France.
- To analyze trends in donation, waitlist dynamics, and transplant outcomes.
- To identify areas for improvement in heart transplant programs.
Main Methods:
- Utilized data from the French national transplant agency registry.
- Analyzed characteristics of donors, candidates, and recipients.
- Examined waitlist and post-transplant outcomes.
Main Results:
- Declining brain-dead heart donors, increased use of high-risk donors.
- High rates of cardiogenic shock among candidates and recipients.
- Significant waitlist mortality and early graft dysfunction.
- Geographic disparities in transplant rates persist.
- Median post-transplant survival of 150 months; pediatric survival 222 months.
Conclusions:
- The report offers a detailed status of heart transplantation in France.
- Future improvements anticipated with cost coverage for perfusion machines and donation after circulatory death.
- The French heart transplant landscape is evolving.

