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Published on: February 9, 2022

Bronchodilator reversibility in children with cystic fibrosis: prevalence and associated factors

Astrid Harvey1, Nicole Beydon2, Guillaume Thouvenin1

  • 1Sorbonne Université, Inserm U938, Centre de Recherche Saint-Antoine (CRSA), Assistance Publique - Hôpitaux de Paris (AP-HP), Hôpital Trousseau, Service de Pneumologie Pédiatrique, GRC SoLID, 26 Avenue du Dr Netter, Paris 75012, France.

Archives De Pediatrie : Organe Officiel De La Societe Francaise De Pediatrie
|July 24, 2026
PubMed

Insights

Approximately one-third of children with cystic fibrosis (CF) exhibit significant bronchodilator reversibility (BDR), often detected via respiratory resistance measurements. Comprehensive PFTs are key for guiding CF treatment.

Area of Science:

  • Pediatric Pulmonology
  • Respiratory Medicine
  • Cystic Fibrosis Research

Background:

  • Respiratory disease significantly impacts cystic fibrosis (CF) prognosis.
  • Bronchodilator reversibility (BDR) prevalence and determinants in pediatric CF patients are not well-understood.

Purpose of the Study:

  • To determine the prevalence of significant BDR in children with CF (CwCF).
  • To identify clinical and microbiological factors associated with BDR in CwCF.

Main Methods:

  • Retrospective analysis of 48 CwCF under 20 years old, including 164 pulmonary function tests (PFTs).
  • BDR assessed using spirometry and respiratory resistance (Rint) via interrupter technique.
  • Univariate and multivariate logistic regression used to identify BDR predictors.

Main Results:

  • Significant BDR (BDR+) found in 33% of CwCF, primarily detected by decreased Rint (87.5%).
  • BDR+ independently associated with obstructive ventilatory defect and number of PFTs performed.
  • Pseudomonas aeruginosa colonization linked to BDR+ in univariate but not multivariate analysis.

Conclusions:

  • Significant BDR occurs in about one-third of CwCF, with respiratory resistance being a key detection method.
  • Emphasizes comprehensive respiratory monitoring, including resistance, for individualized CF care.
  • Supports functionally guided use of inhaled therapies in pediatric CF patients.
Abstract

Keywords:
Airway resistanceBronchodilator reversibilityCystic fibrosisObstructive ventilatory defectPediatricsPulmonary function tests

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