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m6A reader IGF2BP2 mediates airway remodeling by stabilizing Dixdc1 in asthma pathogenesis
Xiao-Mang Li1, Bi-Wen Mo2, Yan Gao1
1Guilin Medical University, Guilin, 541004, Guangxi, China.
Pulmonary Pharmacology & Therapeutics
|July 24, 2026
Summary
N6-methyladenosine (m6A) modification regulates gene expression. This study reveals IGF2BP2 stabilizes Dixdc1 mRNA in asthma, driving airway remodeling. Resveratrol may offer therapeutic potential by targeting this epitranscriptomic pathway.
Area of Science:
- Epitranscriptomics
- Molecular Biology
- Respiratory Medicine
Background:
- N6-methyladenosine (m6A) is a key post-transcriptional regulator.
- m6A-related genes are implicated in asthma pathogenesis.
- The precise molecular mechanisms require experimental validation.
Purpose of the Study:
- To experimentally validate m6A-related genes in asthma.
- To elucidate the regulatory role of IGF2BP2 in airway smooth muscle cells.
- To identify therapeutic targets for asthma treatment.
Main Methods:
- In-vitro asthma model using PDGF-BB-stimulated rat airway smooth muscle cells (AMSCs).
- qRT-PCR, CCK-8, wound healing assays, mRNA-sequencing, and RIP-seq.
- Analysis of human and rat asthma datasets.
Main Results:
- Igf2bp2 knockdown inhibited AMSC proliferation and migration.
- IGF2BP2 was found to stabilize Dixdc1 mRNA.
- IGF2BP2-DIXDC1 co-expression correlated with asthma severity.
- Resveratrol treatment attenuated asthma phenotypes.
Conclusions:
- IGF2BP2 stabilizes Dixdc1 mRNA, promoting airway remodeling in asthma via an m6A-dependent pathway.
- The IGF2BP2-DIXDC1 axis represents a potential therapeutic target.
- Resveratrol shows promise for treating asthma by modulating this epitranscriptomic pathway.
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