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Prognostic Systematic Reviews: Challenges and Insights-An Example
Jana Khawandi1, Daniel G Rayner2, Vinamratha Rao1
1Evidence-Based Practice and Impact Center, Department of Internal Medicine, University of Kansas Medical Center, Kansas City, KS, USA.
Journal of Clinical Epidemiology
|July 24, 2026
Summary
Conducting prognostic systematic reviews for Autosomal Dominant Polycystic Kidney Disease (ADPKD) biomarkers is complex. This review details challenges in data analysis and interpretation, offering insights for future research.
Area of Science:
- Biomedical Research
- Medical Informatics
- Genetics
Background:
- Systematic reviews of prognostic factors present significant challenges, particularly with extensive evidence.
- Autosomal Dominant Polycystic Kidney Disease (ADPKD) research involves numerous prognostic biomarkers.
Purpose of the Study:
- To describe challenges and lessons learned from a systematic review and meta-analysis of prognostic biomarkers in ADPKD.
- To provide practical insights for researchers conducting similar prognostic reviews.
Main Methods:
- Documenting challenges encountered at each stage of the systematic review process.
- Group discussions to identify further issues and potential process improvements.
Main Results:
- Data analysis and interpretation emerged as the most challenging step due to inconsistent data reporting.
- Screening and data extraction were also difficult due to the large volume of studies, many not primarily prognostic.
Conclusions:
- The identified challenges and provided tips aim to streamline future prognostic systematic reviews.
- This work serves as a guide for researchers focusing on prognostic factors in ADPKD and other conditions.
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