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Starting from the syndrome: A comprehensive review on mononeuropathy multiplex
V Loser1, M Théaudin1, V Dunet2
1Nerve-Muscle Unit, Service of Neurology, Department of Clinical Neurosciences, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Revue Neurologique
|July 24, 2026
Summary
Mononeuropathy multiplex, a rare nerve disorder, requires prompt recognition. This review focuses on its clinical presentation, diagnosis, and causes for neurologists and specialists.
Area of Science:
- Neurology
- Peripheral Nerve Disorders
Background:
- Mononeuropathy multiplex is a distinct clinical syndrome within peripheral nerve disorders.
- It often stems from rare causes and can lead to severe complications.
- Prompt identification by neurologists and neuromuscular specialists is crucial.
Purpose of the Study:
- To review mononeuropathy multiplex, emphasizing its syndromic presentation.
- To consolidate information on clinical features, diagnostic approaches, and etiologies.
- To address the lack of reviews focusing on the syndrome as a diagnostic starting point.
Main Methods:
- Literature review focusing on mononeuropathy multiplex.
- Synthesis of information regarding clinical presentation.
- Compilation of diagnostic workup strategies, including electrophysiological and radiological evaluations.
- Summarization of known etiologies.
Main Results:
- Mononeuropathy multiplex presents a specific pattern of neurological deficits.
- Diagnostic evaluation involves a combination of clinical assessment, nerve conduction studies, and imaging.
- A wide range of rare etiologies can underlie this condition.
Conclusions:
- Mononeuropathy multiplex necessitates a systematic diagnostic approach.
- Understanding the syndromic presentation aids in identifying underlying rare diseases.
- This review provides a comprehensive resource for clinicians managing this disorder.
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