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Mapping fluid-suppressed diffusivity in brain tumors
Cornelia Säll1, Tim Salomonsson2, Irena Grubor2
1From the Department of Medical Radiation Physics (C.S., F.S.), Clinical Sciences, Diagnostic Radiology (T.S., P.C.S., M.N.), Division of Neurosurgery (I.G.), Pathology (X.S.S.), Lund University, Lund, Sweden; Department of Imaging and Function (P.C.S., M.N.), Skåne University Hospital, Lund Sweden and Lund university Bioimaging Center (LBIC) (P.C.S.), Lund university, Lund Sweden. Cornelia.sall@med.lu.se.
A new method maps mean diffusivity in tissue, improving visualization of reduced diffusion in brain tumors by avoiding free water contamination. This technique aids in differentiating tumor types based on diffusion characteristics.
Area of Science:
- Neuroimaging
- Diffusion MRI
- Tumor Microstructure Analysis
Background:
- Apparent diffusion coefficient (ADC) is crucial for tumor microstructure assessment.
- Free water (CSF, edema) can contaminate ADC, obscuring reduced diffusion areas.
- A novel method aims to map diffusivity in brain tumors without free water bias.
Purpose of the Study:
- Evaluate a new method for mapping diffusivity in tissue, free from free water contamination.
- Improve the detection of reduced diffusion in brain tumors.
- Assess the utility of this method in differentiating tumor subtypes.
Main Methods:
- Utilized high b-value spherical b-tensor encoding for fluid-suppressed mean diffusivity mapping.
- Evaluated the method through simulations and 3T MRI data from 60 brain tumor patients (55 gliomas, 5 metastases).
Main Results:
- The new method visualized reduced diffusivity areas more effectively than conventional ADC in simulations and patient data.
- Significantly lower mean diffusivity in tissue compared to ADC was more common in isocitrate dehydrogenase wildtype tumors (glioblastomas).
- Mean diffusivity in tissue showed a significant association with isocitrate dehydrogenase status.
Conclusions:
- Mapping mean diffusivity in tissue enhances the detection of low-diffusivity regions in diffuse gliomas.
- This technique overcomes limitations of conventional ADC maps affected by free water.
- The method shows potential for improved characterization of brain tumors, including IDH status.
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