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Antimicrobial Peptides Produced by Selective Pressure Incorporation of Non-canonical Amino Acids
Published on: May 4, 2018
Luteoagmacins A and B, new antimicrobial agmatine derivatives from a hot spring water-derived Luteococcus sp
Shotaro Hoshino1, Emiko Nagai2,3, Hisayuki Komaki4
1Department of Life Science, Faculty of Science, Gakushuin University, Toshima, Japan. shotaro.hoshino@gakushuin.ac.jp.
Abstract:
Two new agmatine derivatives, luteoagmacins A (1) and B (2), were isolated from the culture extract of the hot spring water-associated actinomycete Luteococcus sp. RD000023. The chemical structures of 1 and 2 were elucidated by spectroscopic analyses, including 1D and 2D NMR spectroscopy, and the structure of 2 was further confirmed by chemical synthesis. Based on disk diffusion and broth microdilution assays using the synthetic material, 2 exhibited broad-spectrum antimicrobial activity against Gram-positive and Gram-negative bacteria, as well as yeast.
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