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Published on: December 1, 2016
Inhalable Mucoadhesive Redox-Triggered Nanotherapeutics for p53-Mediated Lung Cancer Therapy and Metastasis
Yun Seop Shim1,2, Sung Min Han1, Yun Kee Jo1,3,4
1Department of Biomedical Convergence Science and Technology, Advanced Institute of Science and Technology, Kyungpook National University, Daegu, Republic of Korea.
Advanced Healthcare Materials
|July 25, 2026
Summary
This study introduces inhalable nanoparticles for p53 gene therapy to combat metastatic lung cancer. The novel system targets cancer cells, enhancing p53 delivery and effectively suppressing tumor growth and metastasis with improved safety.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Oncology
Background:
- Metastatic lung cancer is a major cause of cancer mortality.
- p53 gene therapy holds promise but faces delivery challenges.
- Inefficient delivery hinders clinical translation of gene therapy for lung cancer.
Purpose of the Study:
- To develop an inhalable nanotherapeutic platform for tumor-selective p53 gene delivery.
- To overcome limitations of traditional gene delivery systems for metastatic lung cancer.
- To investigate the therapeutic efficacy and safety of the novel platform.
Main Methods:
- Developed redox-responsive thiolated chitosan nanoparticles (TCS NPs) for p53 gene delivery.
- Utilized mucoadhesive properties for prolonged pulmonary retention.
- Evaluated cancer selectivity, cytotoxicity, and effects on metastasis-related pathways in vitro and in vivo.
Main Results:
- TCS NPs demonstrated selective cytotoxicity against lung cancer cells with good biocompatibility.
- Treatment restored p53 pathways, upregulating metastasis suppressors and apoptotic factors.
- In vivo studies showed significant tumor suppression and reduced metastasis with excellent safety.
Conclusions:
- The developed inhalable TCS@p53 NPs represent a transformative platform for metastatic lung cancer treatment.
- This system overcomes traditional delivery limitations through tumor-selective targeting and enhanced pulmonary retention.
- The findings support the potential of this nanotherapeutic approach for clinical application in lung cancer therapy.
