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Actionable Incidental Findings at Baseline Lung Cancer Screening: Identifying Opportunities in a Universal Healthcare
Adam Gaisinsky1, Lara Gabrielle Lim2,3, Hussain Alshimali4
1Temerty Faculty of Medicine, University of Toronto, ON, Canada.
Summary
Actionable incidental findings (AIFs) are common in lung cancer screening, but reporting for some significant conditions is low. Standardized reporting and guidance are needed for better AIF management and cost-effectiveness.
Area of Science:
- Radiology
- Pulmonary Medicine
- Health Services Research
Background:
- Lung cancer screening identifies incidental findings beyond lung nodules.
- Actionable incidental findings (AIFs) require further investigation or management.
- Optimizing AIF detection and management is crucial for patient outcomes and healthcare efficiency.
Purpose of the Study:
- To determine the prevalence of AIFs in a high-risk lung cancer screening cohort.
- To identify system-level quality improvement opportunities for AIF detection and management.
- To assess alignment of AIF management recommendations with existing guidelines.
Main Methods:
- Retrospective cohort study of individuals undergoing baseline lung cancer screening CT exams.
- Extraction of structured CT report text to identify AIFs, their descriptions, and management recommendations.
- Comparison of AIF prevalence with guideline literature using statistical tests to identify reporting gaps.
Main Results:
- 11.7% of 3169 individuals had AIFs, with coronary artery calcification, thyroid lesions, and interstitial lung abnormalities being most common.
- Low reporting rates for bone mineral density, vertebral fractures, and indeterminate adrenal lesions were observed.
- Management recommendations generally aligned with provincial guidance, but gaps in reporting for specific AIFs were noted.
Conclusions:
- AIFs are frequently identified during lung cancer screening, but reporting for certain significant findings is suboptimal.
- Standardized reporting protocols for AIFs are necessary to ensure comprehensive patient care.
- Program-specific guidance is essential to manage AIFs effectively and address downstream healthcare costs.
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Primary care promotes wellness and prevents disease. This care includes health promotion, education, protection (such as immunizations), early disease screening, and environmental considerations. Settings providing this type of healthcare include physician offices, public health clinics, school nursing, and community health nursing.
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