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Transcatheter Pulmonary Valve Replacement from Autologous Pericardium with a Self-Expandable Nitinol Stent in an Adult Sheep Model
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Transcatheter Pulmonary Valve Replacement from Autologous Pericardium with a Self-Expandable Nitinol Stent in an Adult Sheep Model

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Clinical outcomes of injectable and conventional pulmonary valve replacement in severe pulmonary regurgitation

Sercan Tak1, Murat Koç2, Ali Kutsal3

  • 1Department of Cardiovascular Surgery, Faculty of Medicine, Gazi University, Ankara, Turkiye.

Turkish Journal of Medical Sciences
|July 25, 2026
PubMed

Insights

Injectable pulmonary valve replacement in pediatric patients shows favorable early outcomes and comparable long-term function to conventional methods. This less invasive approach offers a safe alternative for managing pulmonary regurgitation after tetralogy of Fallot repair.

Area of Science:

  • Cardiovascular Surgery
  • Pediatric Cardiology
  • Biomedical Engineering

Background:

  • Pulmonary regurgitation is a common complication after tetralogy of Fallot repair, often necessitating pulmonary valve replacement.
  • Injectable bioprosthetic valves present a less invasive option compared to traditional surgical valve replacement.
  • Limited comparative data exists for injectable valves in pediatric populations.

Purpose of the Study:

  • To evaluate and compare the short-term and long-term clinical outcomes of injectable pulmonary valve replacement versus conventional pulmonary valve replacement.
  • To assess the safety and efficacy of injectable pulmonary valve replacement in pediatric patients with severe pulmonary regurgitation post-tetralogy of Fallot repair.

Main Methods:

  • Retrospective study of 22 pediatric patients undergoing pulmonary valve replacement.
  • Patients were stratified into two groups: injectable (n=9) and conventional (n=13).
  • Outcomes assessed included early postoperative parameters and long-term valve function over a mean follow-up of 10.5 years.

Main Results:

  • The injectable group demonstrated significantly shorter ICU stays, reduced mechanical ventilation duration, less chest tube drainage, and shorter hospital stays.
  • Both groups exhibited similar long-term valve function and right ventricular remodeling.
  • Excellent freedom from reintervention (100%) was observed in both cohorts during the follow-up period.

Conclusions:

  • Injectable pulmonary valve replacement is a safe alternative for pediatric patients with pulmonary regurgitation post-tetralogy of Fallot repair.
  • It offers favorable early outcomes and long-term valve performance comparable to conventional surgical replacement.
  • Optimal results depend on clinical experience and precise patient selection.
Abstract

Keywords:
Tetralogy of Fallotcongenital heart defectsheart surgical procedurepulmonary regurgitationpulmonary valve

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