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Updated: Aug 5, 2026
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Evaluation of the Efficacy And Toxicity of RNAs Targeting HIV-1 Production for Use in Gene or Drug Therapy
Published on: September 5, 2016
Long Non-Coding RNAs: Allies and Enemies of HIV Infection
T F Kikhai1,2, A V Mashkovskaia3, T S Oretskaya2
1Lomonosov Moscow State University, Faculty of Chemistry, Moscow, 119991 Russia.
Acta Naturae
|July 25, 2026
Summary
Long non-coding RNAs (lncRNAs) significantly impact viral infections, including human immunodeficiency virus type 1 (HIV-1). This review explores how lncRNAs regulate HIV-1 replication and latency, offering potential diagnostic and therapeutic strategies.
Area of Science:
- Molecular Biology
- Virology
- Genetics
Background:
- Long non-coding RNAs (lncRNAs) are crucial regulators of gene expression.
- Viral infections, such as human immunodeficiency virus type 1 (HIV-1), involve complex host-pathogen interactions.
- The role of lncRNAs in viral pathogenesis is an emerging area of research.
Purpose of the Study:
- To review and summarize current knowledge on lncRNAs associated with HIV-1.
- To elucidate the regulatory roles of lncRNAs in HIV-1 replication and latency.
- To explore the potential of lncRNAs as diagnostic markers and therapeutic targets for HIV-1 infection.
Main Methods:
- Literature review of studies investigating lncRNAs and HIV-1.
- Analysis of data on lncRNA-mediated regulation of viral gene expression.
- Synthesis of information on lncRNA involvement in both active and latent HIV-1 infection phases.
Main Results:
- lncRNAs act as both positive and negative regulators of HIV-1 gene expression.
- lncRNAs influence the active replication cycle of HIV-1.
- lncRNAs modulate the latent phase of HIV-1 infection, affecting proviral DNA transcription.
Conclusions:
- lncRNAs play a significant role in the pathogenesis of HIV-1 infection.
- lncRNAs represent promising diagnostic biomarkers for HIV-1.
- lncRNAs offer potential novel therapeutic targets for developing innovative treatments against HIV-1 and AIDS.
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