Debunking Myths on Hyaluronic Acid Injectable Gels in Clinical Practice

Area of Science:

• Aesthetic Medicine
• Dermatology
• Biomaterials Science

Background:

• Hyaluronic acid (HA)-based soft-tissue fillers are extensively utilized for non-surgical facial rejuvenation.
• Despite their popularity, prevalent misconceptions regarding HA gels exist in public and clinical spheres.
• These misconceptions may negatively influence healthcare providers and patients.

Purpose of the Study:

• To address and clarify common misconceptions surrounding hyaluronic acid injectable gels.
• To provide an evidence-based overview of HA fillers for aesthetic applications.
• To guide safe and effective clinical practice.

Main Methods:

• A narrative, nonsystematic literature review was performed.
• PubMed database was searched for English-language studies, prioritizing high-level evidence.
• Expert opinions from international aesthetic medicine specialists were incorporated.

Main Results:

• HA gels are biodegradable, temporary (4-18 months), and reversible with hyaluronidase.
• Current HA fillers show no toxicity at clinical concentrations; risks stem from technique, not product.
• Biostimulatory effects and improved quality of life are associated with HA treatments.

Conclusions:

• Published evidence contradicts widespread misconceptions about HA injectable gels.
• The evidence base is varied in quality, necessitating careful interpretation.
• Enhanced practitioner education, planning, and patient communication are crucial for safe HA filler use.