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Updated: Aug 5, 2026

Dual-Dye Optical Mapping of Hearts from RyR2R2474S Knock-In Mice of Catecholaminergic Polymorphic Ventricular Tachycardia
Published on: December 22, 2023
Trans-2,3-enoyl-CoA reductase-like-related catecholaminergic polymorphic ventricular tachycardia in a child: Clinical
E K Kulbachinskaya1, A A Pushkov2, V V Bereznitskaya1
1Center for Cardiac Arrhythmias, Veltischev Research and Clinical Institute for Pediatrics and Pediatric Surgery, Pirogov Russian National Research Medical University, Moscow, Russia.
Abstract:
Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a rare but potentially fatal inherited arrhythmia. We report a 7-year-old child with CPVT associated with a homozygous trans-2,3-enoyl-CoA reductase-like c.730 + 1G>C variant. To our knowledge, this variant has not been previously reported in the indexed peer-reviewed literature. Prophylactic implantation of an implantable cardioverter defibrillator before symptom onset proved lifesaving during a subsequent ventricular fibrillation episode despite beta-blocker therapy.
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