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Spontaneous Murine Model of Anaplastic Thyroid Cancer
Published on: February 3, 2023
Papillary Thyroid Cancer With Cutaneous Metastasis: A Case Report and Literature Review
Yi-Qing Gao1, Xin-Lu Yin1, Lu-Ying Zheng2
1Department of Head and Neck Surgery, Renji Hospital, School of Medicine Shanghai Jiao Tong University (SJTU) Shanghai China.
Summary
Cutaneous metastasis of papillary thyroid carcinoma is rare and can be misdiagnosed. This case highlights the importance of careful evaluation of skin lesions in thyroid cancer patients for early detection and prognosis.
Area of Science:
- Oncology
- Dermatology
- Pathology
Background:
- Cutaneous metastasis of papillary thyroid carcinoma is uncommon.
- Skin metastasis in thyroid cancer is a poor prognostic indicator.
- Pathophysiology and genetic factors of skin metastasis require further investigation.
Purpose of the Study:
- To report a rare case of cutaneous metastasis of papillary thyroid carcinoma.
- To emphasize the diagnostic challenges and clinical presentation of skin metastasis.
- To discuss the prognostic significance of skin metastasis in thyroid cancer.
Main Methods:
- A case study of a 29-year-old female with a history of thyroid cancer.
- Clinical examination and biopsy of a neck skin mass.
- Immunohistochemical analysis of tumor cells (TTF-1, TG, Ki67, PAX-8, GCDFP, ER, PR, GATA-3).
Main Results:
- The patient presented with a hyperpigmented neck lesion 8 years post-surgery.
- Microscopic and immunohistochemical findings confirmed papillary thyroid carcinoma metastasis.
- Tumor cells expressed TTF-1 and PAX-8, with variable PR expression.
Conclusions:
- Skin metastases from thyroid cancer are rare and can be easily misdiagnosed.
- Careful selection and diagnosis of skin lesions in the head and neck area are crucial during thyroid cancer follow-up.
- Prompt identification of skin metastasis is vital for patient management and prognosis.
