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Obstructive Sleep Apnea and BMI, Body Fat Percentage in the East Asian Population: A Bidirectional and Multivariate
Rui Fan1, Wen-Jun Lu1, Hua Zhang2
1Department of Otorhinolaryngology Peking University Third Hospital Beijing China.
Summary
Body fat percentage and body mass index (BMI) are significant risk factors for obstructive sleep apnea (OSA) in East Asians. Higher body fat percentage independently increases OSA risk, suggesting its potential as a screening indicator.
Area of Science:
- Genetics
- Epidemiology
- Sleep Medicine
Background:
- Obstructive sleep apnea (OSA) is a prevalent condition linked to obesity.
- The causal relationship between OSA and obesity metrics like body fat percentage and BMI requires further investigation, particularly in East Asian populations.
Purpose of the Study:
- To investigate the bidirectional causal relationship between obstructive sleep apnea (OSA) and obesity indicators (body fat percentage, BMI) in the East Asian population.
- To explore the independent effect of body fat percentage on OSA risk, controlling for BMI.
Main Methods:
- Utilized bidirectional and multivariate Mendelian randomization analyses.
- Employed genetic data for OSA, body fat percentage, and BMI from Japanese and Taiwanese biobanks.
- Applied the Inverse Variance Weighted method as the primary analytical approach.
Main Results:
- A significant forward causal relationship was found between body fat percentage and OSA (β=1.272, p=0.011).
- A significant forward causal relationship was also observed between BMI and OSA (β=0.817, p=0.008).
- No significant reverse causal relationships were detected between OSA and either body fat percentage or BMI.
Conclusions:
- Both body fat percentage and BMI are confirmed as significant risk factors for OSA in East Asians.
- Body fat percentage demonstrates an independent effect on OSA risk, irrespective of BMI.
- Body fat percentage holds potential as a novel indicator for OSA screening and diagnosis.
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01:21Sleep Apnea
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01:24Obesity
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