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Updated: Aug 5, 2026
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VDJ-Seq: Deep Sequencing Analysis of Rearranged Immunoglobulin Heavy Chain Gene to Reveal Clonal Evolution Patterns of B Cell Lymphoma
Published on: December 28, 2015
Concurrent B-cell acute lymphoblastic leukemia and plasma cell neoplasm with plasmablastic features supporting
Antonija Babić1, Ivana Franić Šimić2, Josip Knežević1
1Department of Laboratory Immunology, Clinical Department of Laboratory Diagnostics, University Hospital Centre Zagreb, Zagreb, Croatia.
Frontiers in Oncology
|July 25, 2026
Summary
This case study details a rare instance of B-cell acute lymphoblastic leukemia (B-ALL) and plasma cell neoplasm (PCN) co-occurring in one patient. Genomic analysis suggests early clonal divergence from a common progenitor, offering insights into lymphoid malignancy evolution.
Area of Science:
- Hematology
- Oncology
- Genetics
Background:
- B-cell malignancies are diverse, with rare reports of co-occurring distinct lymphoid entities.
- Simultaneous occurrence of B-cell acute lymphoblastic leukemia (B-ALL) and plasma cell neoplasm (PCN) is exceptionally rare.
- Such cases offer insights into clonal architecture and evolutionary pathways of lymphoid malignancies.