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Updated: Aug 6, 2026
Application of Granger Causality Analysis of the Directed Functional Connection in Alzheimer's Disease and Mild Cognitive Impairment
Published on: August 7, 2017
Multi-Index Brain Function-Cognition Correlation in Amnestic Mild Cognitive Impairment: A Resting-State fMRI Study
ShuPing Chen1,2,3,4,5, Haoyu Huang6,7, Xiaoyi Xu1,2,3,4
1Center of Rehabilitation Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Abstract:
BackgroundThis study aimed to investigate the correlation between multi-metric resting-state fMRI (rs-fMRI) changes and cognitive performance in amnestic mild cognitive impairment (aMCI), moving beyond single-metric analyses.MethodsForty aMCI patients and twenty healthy controls underwent 3.0T rs-fMRI and neurocognitive assessment (MoCA, DST). Multiple rs-fMRI metrics (ReHo, ALFF/fALFF, RSFC) were analyzed for their association with cognition.ResultsaMCI patients showed increased frontal ReHo, decreased ALFF in default mode network hubs, and reduced prefrontal-parietal-temporal RSFC. Frontal hyper-synchronization correlated negatively with cognitive scores, while DMN ALFF correlated positively.ConclusionsMulti-metric fMRI detects characteristic functional alterations in aMCI, indicating regional brain damage or compensatory changes linked to cognitive performance.
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