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A Review of Informed Consent for Porcine Islet Xenotransplantation to Treat Type 1 Diabetes
Jennifer Kovalcik1, Sheetal Mohanty1, Mairead Higgins1
1Rowan-Virtua School of Osteopathic Medicine, Stratford, New Jersey, USA.
Purpose:
The objective of this review is to map and synthesize the existing literature regarding informed consent for porcine islet xenotransplantation for the treatment of Type 1 Diabetes.
Methods:
The search was conducted in May 2025 through the following databases: PubMed, SCOPUS, EMBASE, and CINAHL. Broad search strings were used to combine the text words "islet" AND "xenotransplantation" AND "consent" or similar permutations and combinations. Peer-reviewed articles were included if they were published between January 1990 and May 2025 and written in English. The final search results were manually exported to a reference manager system (Zotero), and the PRISMA-ScR flow diagram was created to depict the data extraction process.
Results:
From 134 sources, 7 articles met eligibility for this scoping review. Although clinical studies have been sporadically conducted, there is a lack of literature describing informed consent for islet xenotransplantation.
Conclusion:
This review highlighted a scarcity of scholarly discourse and published guidance on informed consent specifically in the context of islet xenotransplantation.
