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Pulsed Nd:YAG versus continuous-wave laser photobiomodulation for orthodontic pain: a split-mouth RCT
Jingchen Jia1, Qunwen Niu2, Yuan Gao1
1Department of Stomatology, Air Force Medical Center, Beijing, China.
Lasers in Medical Science
|July 25, 2026
Summary
Pulsed neodymium-doped yttrium-aluminum-garnet (Nd:YAG) laser therapy effectively reduces orthodontic pain. A 15 Hz frequency demonstrated optimal analgesic effects, decreasing tooth sensitivity and pain duration compared to other frequencies.
Area of Science:
- Biomedical Engineering
- Dental Science
- Pain Management
Background:
- Local pain after orthodontic tooth movement impacts patient experience and compliance.
- Photobiomodulation therapy (PBMT) using pulsed lasers offers a potential solution for pain relief.
Purpose of the Study:
- To evaluate the analgesic efficacy of pulsed Nd:YAG laser at various frequencies for orthodontic pain.
- To determine optimal laser parameters for pain management during orthodontic treatment.
Main Methods:
- A randomized, double-blind, controlled trial involving 96 patients undergoing orthodontic treatment.
- Comparison of pulsed Nd:YAG laser (10, 15, 20 Hz) and continuous-wave semiconductor laser groups.
- Assessment of pain using digital pressure algometry (pressure-pain thresholds) and visual analogue scales (VAS).
Main Results:
- Pulsed Nd:YAG laser, particularly at 15 Hz, significantly increased pressure-pain thresholds compared to the semiconductor laser.
- The 15 Hz pulsed Nd:YAG group showed significantly lower VAS scores and shorter pain duration.
- All laser treatments resulted in higher pressure-pain thresholds and lower VAS scores on the treated side compared to the non-treated side.
Conclusions:
- Both pulsed Nd:YAG and continuous-wave semiconductor lasers effectively alleviate orthodontic pain.
- The 15 Hz pulsed Nd:YAG laser (at 60 J total energy) appears optimal for reducing tooth sensitivity and pain duration.
- Optimal laser parameters, such as 15 Hz frequency, 150 µs pulse duration, and 0.5 W power, warrant further investigation for orthodontic pain relief.
Keywords:
Orthodontic painOrthodontic treatmentPhotobiomodulation therapyPulsed neodymium doped yttrium aluminum garnet laser
