Dynamic risk stratification using the modified Cekirge-Saatci classification (mCSC) predicts recanalization after...

To evaluate the temporal evolution of the modified Cekirge-Saatci classification (mCSC) after flow diverter (FD) treatment and to investigate its predictive value for recanalization using an exploratory mCSC-based risk stratification approach.

This retrospective study included 50 patients with intracranial aneurysms treated with FD between 2015 and 2026. Patients were stratified into no-risk, intermediate-risk, and high-risk levels based on mCSC classes at 4- and 12-month angiographic follow-up. Clinical, morphological, and treatment-related variables were analyzed. The association between mCSC risk levels and recanalization was assessed using univariate and multivariate logistic regression analyses.

The mean age was 55.2 ± 12.9 years, and 70% of patients were female. Recanalization occurred in 28% of cases during a mean follow-up of 104.8 ± 24.4 months. In univariate analysis, hypertension (71.4% vs. 36.1%, p = 0.024) and aneurysm size (median 5.5 mm vs. 3.5 mm, p = 0.036) were associated with recanalization. Both 4-month and 12-month mCSC risk levels were significantly correlated with recanalization (p = 0.015 and p = 0.014, respectively). In multivariate analysis, the 12-month mCSC risk level remained associated with recanalization within the exploratory multivariable model, with higher-risk categories demonstrating increased odds of recanalization (OR: 31.031, p = 0.015). Temporal analysis demonstrated dynamic transitions between risk categories, with a subset of patients progressing from no to high risk over time.

The mCSC should be considered a dynamic rather than a static classification system. A risk-based interpretation and longitudinal evaluation of mCSC may provide prognostic information regarding recanalization and may assist future development of individualized follow-up strategies after FD treatment.