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Association between depressive symptoms, CRP and metabolism-related indicators in Han Chinese patients with chronic

Xianlin Sun1, Yachen Feng1, Jinglei Zhang2

  • 1Department of Psychiatry, The Fourth Affiliated Hospital of Anhui Medical University, Hefei, Anhui Province, China.

Schizophrenia Research
|July 25, 2026
PubMed

Insights

Depressive symptoms affect over a quarter of chronic schizophrenia patients. Psychotic symptoms, insomnia, and elevated C-reactive protein (CRP) are significant risk factors.

Area of Science:

  • Psychiatry
  • Neuroscience
  • Clinical Medicine

Background:

  • Depressive symptoms are common in chronic schizophrenia.
  • Pathological mechanisms of depression in schizophrenia are not fully understood.
  • This study focuses on Han Chinese patients with chronic schizophrenia.

Purpose of the Study:

  • Estimate the prevalence of depressive symptoms in Han Chinese patients with chronic schizophrenia.
  • Investigate associations between depressive symptoms and clinical features, metabolic parameters, and inflammatory biomarkers.
  • Identify independent risk factors for depressive symptoms.

Main Methods:

  • 305 patients with chronic schizophrenia and 182 healthy controls were enrolled.
  • Clinical symptoms were assessed using standardized scales, including the Calgary Depression Scale for Schizophrenia (CDSS).
  • Plasma C-reactive protein (CRP) and metabolism-related indicators were measured; logistic regression and ROC curve analyses were performed.

Main Results:

  • The prevalence of depressive symptoms was 26.2% in patients with chronic schizophrenia.
  • Independent risk factors for depressive symptoms included total Positive and Negative Syndrome Scale (PANSS) score, Insomnia Severity Index (ISI) score, and CRP.
  • Integration of total PANSS score, ISI score, and CRP showed superior discriminative capacity for identifying depressive symptoms (AUC = 0.790).

Conclusions:

  • Depressive symptoms impact over 25% of Han Chinese patients with chronic schizophrenia.
  • Depression occurrence is associated with psychotic symptoms, insomnia, extrapyramidal side effects, and elevated CRP and metabolic biomarkers.
  • These findings highlight the importance of monitoring and managing depressive symptoms in schizophrenia.
Abstract

Keywords:
C-reactive proteinChronic schizophreniaDepressive symptomsMetabolic indicatorsPsychopathology

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