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Effect of tablet press residence time distribution on material traceability in a Direct Compression Mini-Batch
Peter Boehling1, Johan Remmelgas1, Johannes Poms1
1Research Center Pharmaceutical Engineering GmbH, Graz, Austria.
None:
Continuous Direct Compression via Mini-Batch Blending (CDC via MBB) is gaining traction as an innovative manufacturing technology in the pharmaceutical industry. In the first part of this work, the residence time distribution (RTD) of a feed frame was characterized experimentally and by using discrete element method (DEM) simulations. The RTD was used to simulate different disturbance scenarios for the feed frame. In this second part, the work is extended to evaluate the effects of various hopper and impeller configurations on the RTD of materials within the feed frame, focusing on how different designs influence material mixing and the propagation of disturbances. The paper utilizes DEM simulations to analyze the RTD in six different feed frame variants. The RTD is modeled using the generalized n-CSTR model, which is then used to predict the influence of process disturbances on tablet composition. The paper provides insights on the relationship between feed frame design, material traceability and disturbance propagation.
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