Related Experiment Videos

Cardiovascular risk is increased in patients with Paget's disease of bone: Insights from the CARTaGENE cohort

Catherine Champagne1, Clément Vachey2, Aurélie Dufour2

  • 1Faculty of Medicine, Department of Medicine, Université Laval, Quebec, QC, Canada.

Bone
|July 25, 2026
PubMed

Insights

Paget's disease of bone (PD) is linked to a higher risk of major adverse cardiovascular events (MACE) in middle-aged adults. However, Paget's disease did not show a significant association with arterial stiffness in this study.

Area of Science:

  • Cardiology
  • Endocrinology
  • Rheumatology

Background:

  • Paget's disease of bone (PD) is a chronic condition affecting bone metabolism.
  • The potential cardiovascular implications of PD, including major adverse cardiovascular events (MACE) and arterial stiffness, require further investigation.

Purpose of the Study:

  • To determine if Paget's disease of bone increases the risk of MACE.
  • To assess the association between PD and arterial stiffness in middle-aged individuals.

Main Methods:

  • Analysis of the CARTaGENE cohort (n=19,990) aged 40-69 years, linked to healthcare administrative databases.
  • Inclusion of PD diagnosis and MACE data from 1997-2021, with comorbidities and arterial stiffness measured at recruitment.
  • Propensity-score matching (1:3) and time-to-event analyses using Cox and Fine-Gray models were employed.

Main Results:

  • 101 participants (0.5%) had PD; they were older and had higher diabetes prevalence.
  • PD was associated with a significantly increased risk for MACE-3 (HR 1.86) and MACE-5 (HR 2.06).
  • No significant associations were found between PD and arterial stiffness parameters (augmentation index, estimated pulse wave velocity).

Conclusions:

  • Paget's disease of bone is an independent risk factor for major adverse cardiovascular events.
  • Paget's disease of bone is not significantly associated with arterial stiffness.
Abstract

Keywords:
Paget's disease of boneaugmentation indexcardiovascular riskepidemiologypropensity score matchingpulse wave velocity

Related Concept Videos

Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...