[Myelofibrosis as a cause of non-cirrhotic portal hypertension]

Primary myelofibrosis is a chronic myeloproliferative neoplasm characterised by extramedullary hematopoiesis. Portal hypertension represents a significant cause of mortality in these patients. Diagnosis of portal hypertension is typically based on clinical manifestations and is often confirmed by upper gastrointestinal endoscopy, which allows for the identification of oesophageal varices and facilitates endoscopic intervention. Management options include general supportive measures, chemotherapy, splenectomy, and radiation therapy. This report describes a 53-year-old woman with a history of myelofibrosis who presented with abdominal pain and anaemia. Upper gastrointestinal video endoscopy revealed oesophageal varices, and subsequent confirmation of portal hypertension prompted a percutaneous liver biopsy, which demonstrated myelofibrosis. After appropriate management, the patient had a favourable clinical outcome.