Related Experiment Video
Updated: Aug 6, 2026
07:27
Exergaming in Older People Living with HIV Improves Balance, Mobility and Ameliorates Some Aspects of Frailty
Published on: October 6, 2016
Early Warning and Behavioural Intervention on the Cardiovascular Disease Risk in People Living with HIV: A
Yuyin Zhou1,2, Chunhui Yan3, Zhonghua Xia4
1School of Public Health, Zhejiang University School of Medicine, Hangzhou, China.
Infectious Diseases and Therapy
|July 25, 2026
Summary
A study found that informing people with HIV (PLWH) about their cardiovascular disease (CVD) risk and providing personalized interventions improved their understanding of CVD and reduced risky behaviors. This approach is crucial for managing chronic conditions in aging PLWH populations.
Area of Science:
- Public Health
- Cardiology
- Infectious Diseases
Background:
- Antiretroviral therapy (ART) has transformed Human Immunodeficiency Virus (HIV) infection into a manageable chronic condition.
- Increased life expectancy in people living with HIV (PLWH) leads to a higher prevalence of non-communicable diseases, particularly cardiovascular disease (CVD).
- Traditional risk factors significantly contribute to CVD in PLWH, underscoring the need for targeted interventions.
Purpose of the Study:
- To evaluate the effectiveness of a risk warning and behavioral intervention strategy on cardiovascular disease (CVD) risk factors in people living with HIV (PLWH).
- To assess the impact of the intervention on CVD cognitive levels and health-related behaviors among PLWH.
- To determine if personalized risk information and behavioral reinforcement can mitigate CVD risk in this population.
Main Methods:
- A multicenter, non-randomized controlled trial involving six AIDS-designated hospitals in Zhejiang Province.
- Intervention group received personalized 5/10-year CVD risk assessments and behavioral reinforcement; control group received routine health education.
- Propensity score matching (PSM) and generalized estimating equation (GEE) were used to analyze data collected at baseline, 3 months, and 6 months.
Main Results:
- The intervention group showed significant improvements in CVD cognitive level compared to the control group (2.30 vs. 0.41 points increase, P=0.028).
- A notable increase in participants abstaining from alcohol and a decrease in sedentary time were observed in the intervention group (P<0.05).
- While the intervention group exhibited greater reductions in smoking and drinking rates and higher physical activity compliance, these did not reach statistical significance compared to the control group.
Conclusions:
- Risk warning and behavioral intervention effectively enhanced CVD awareness among people living with HIV (PLWH).
- The intervention demonstrated a positive impact on reducing the frequency of certain health risk behaviors, although complete cessation of smoking or alcohol use was not achieved.
- These findings highlight the potential of targeted interventions to manage cardiovascular risk factors in the growing population of aging PLWH.
Related Concept Videos
01:26Coronary Artery Disease IV: Preventive Measures
Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
01:28Hypertension IV: Drug Therapy and Lifestyle Modifications
Multiple classes of antihypertensive medications are employed in treating hypertension. The most commonly recommended first-line treatments include:Thiazide Diuretics, such as chlorthalidone, increase sodium and water excretion from the body, reducing blood volume and blood pressure.Angiotensin-converting enzyme inhibitors, like lisinopril, block the conversion of angiotensin I to II, a potent vasoconstrictor lowering blood pressure.Angiotensin II Receptor Blockers (ARBs) prevent angiotensin II...
01:30Hypertension III: Clinical Manifestations and Diagnostic Studies
Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
01:26Atherosclerosis III: Management
Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
01:20Blood Studies for Cardiovascular System I: Cardiac Biomarkers
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
01:30Coronary Artery Disease I: Introduction
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...