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Giant Centrifugal Miliaria Profunda
Ruth Alperovich1, Anthony J Mancini2, Daniela Montanari3
1Department of Dermatology, Hospital del Niño Jesús, Tucumán, Argentina.
Journal of Cutaneous Pathology
|July 25, 2026
Summary
Giant centrifugal miliaria profunda (GCMP) is a rare infant skin condition characterized by expanding plaques. One case presented with a genetic RASopathy, highlighting a potential link.
Area of Science:
- Dermatology
- Pediatrics
- Genetics
Background:
- Miliaria profunda results from sweat duct obstruction and rupture below the epidermis.
- Giant centrifugal miliaria profunda (GCMP) is a rare variant in infants, presenting as expanding annular plaques.
- Histological findings include hyperkeratosis, acanthosis, and inflammatory infiltrates.
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