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Published on: October 18, 2024
Clinical Outcomes of Postponing Oocyte Retrieval Beyond 40 h After Trigger With Diclofenac Pretreatment Compared With
Rang Liu1,2,3, Xinyi Pan1,2,3, Rui Xiang1,2,3
1Reproductive Medicine Center The Sixth Affiliated Hospital, Sun Yat-Sen University Guangzhou Guangdong China.
Purpose:
This study aimed to compare outcomes of delaying oocyte retrieval beyond 40 h post-trigger with diclofenac versus the conventional workflow.
Methods:
A total of 4912 cycles were retrospectively screened. Eighty-four delayed cycles and 168 routine cycles from patients who received a single trigger in their first cycle were matched at a 1:2 ratio for age, AMH, COS protocol, and ICSI use and compared.
Results:
The ratio of the number of oocytes retrieved to the number of follicles ≥ 14 mm on trigger day was significantly higher in the delayed group (1.27 ± 0.42 vs. 1.14 ± 0.47, p = 0.031). The rates of maturation (78.9% vs. 78.8%), fertilization (64.0% vs. 64.6%), and blastulation (63.8% vs. 68.5%) were comparable (all p > 0.05). Biochemical pregnancy rates in fresh cycles were numerically lower in the delayed group (38.4% vs. 47.0%), while clinical pregnancy rates were similar between groups in both fresh (38.4% vs. 41.1%) and frozen-thawed cycles (51.2% vs. 52.8%) (all p > 0.05).
Conclusions:
Delaying oocyte retrieval beyond 40 h post-trigger with diclofenac could be feasible to enhance clinical operational flexibility. Further research is warranted to identify subgroups that may benefit most and to optimize strategies adapted to this extension.
