PCN-224(M)@Fe₃O₄/CS/PVA composite nanofibers exhibiting efficient photocatalytic performance for antimicrobial

Bacterial infection caused by drug-resistant bacteria has become a serious social problem and a grave threat to human health. Therefore, the development of antibacterial materials that will not induce bacterial resistance has become a research hot spot. In this paper, a series of nanofibers with high antibacterial performance-PCN-224(M)@Fe₃O₄/CS/PVA (M = Zn, Cu, or Fe)-was prepared. These nanofibers combine the photocatalytic antibacterial ability of PCN-224(M), the photodynamic and photothermal effects of Fe₃O₄ nanoparticles, as well as the antibacterial activity of CS and the biocompatibility of PVA, exhibiting excellent broad-spectrum antibacterial performance and recyclability. Antibacterial experiments showed that the nanofibers have significant inhibitory effects on Gram-negative bacteria (E. coli), Gram-positive bacteria (S. aureus), and methicillin-resistant S. aureus (MRSA). Cytotoxicity test showed that these nanofibers had good biocompatibility and low dark toxicity. This study highlights potential application and value of research on new wound dressings and other biomedical fields.