Related Experiment Videos
Asymptomatic Charcot foot in longstanding diabetes
1CABS, F.I.B.M.S., General Surgery Board, Surgical Department, Faculty of Medicine, Al-Anbar University, Al-Ramadi City, Iraq.
Surgery in Practice and Science
|July 26, 2026
Summary
Plain X-rays detected early Charcot osteoarthropathy in over half of diabetic patients, highlighting the need for MRI confirmation. Early detection aids in preventing foot deformity and managing diabetic foot complications.
Area of Science:
- Diabetology
- Radiology
- Orthopedics
Background:
- Charcot neuropathic osteoarthropathy affects 0.1-7.5% of diabetic patients, often misdiagnosed due to subtle early symptoms.
- High rates of undiagnosed cases (0.4-13%) underscore the need for improved detection methods.
Purpose of the Study:
- To evaluate plain X-ray efficacy in detecting preclinical Charcot disease in patients with long-standing type 2 diabetes mellitus.
- To identify early radiographic signs of Charcot osteoarthropathy before clinical deformity develops.
Main Methods:
- A cross-sectional study of 60 adults with type 2 diabetes mellitus (>10 years duration) was conducted.
- Bilateral foot X-rays, clinical/neurological assessments, and HbA1c levels were obtained.
- Short-term follow-up included X-ray and MRI for positive cases.
Main Results:
- Over half (51.7%) of patients showed X-ray changes consistent with Charcot patterns.
- X-ray positivity correlated with older age, longer diabetes duration, higher HbA1c, and increased BMI.
- At 6 months, 19.4% of positive cases showed radiological progression, prompting MRI and offloading.
Conclusions:
- Plain foot X-rays revealed Charcot patterns in a significant proportion of diabetic patients, suggesting potential for early detection.
- Further MRI-validated studies are needed to confirm these radiographic findings before widespread screening.
- Glycemic control and patient education on trauma prevention remain crucial for managing diabetic foot complications.
Related Concept Videos
Diabetic Foot Ulcer
Definition A diabetic foot ulcer (DFU) is a chronic, non-healing wound that develops in individuals with diabetes. It typically occurs on pressure-bearing areas such as the heel, metatarsal heads, or hallux, and carries a high risk of infection and amputation.Pathophysiology • The development of DFUs can be explained by four interconnected mechanisms: neuropathy, ischemia, infection, and impaired wound healing. • Neuropathy is the most common factor. Sensory neuropathy reduces pain perception,...
Diabetic Neuropathy
DefinitionDiabetic neuropathy is nerve damage caused by long-standing diabetes mellitus. It results directly from prolonged high blood sugar levels.PathophysiologyThe pathophysiology of diabetic neuropathy involves both metabolic and vascular disturbances triggered by chronic hyperglycemia.Metabolic injury: Elevated glucose levels activate the polyol pathway within nerve cells, leading to the accumulation of sorbitol and fructose. This increases oxidative stress, disrupts normal nerve...
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation
Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
Complications of Diabetes Mellitus
Diabetes mellitus is a chronic metabolic disorder characterized by persistent hyperglycemia due to insulin deficiency, resistance, or both. Prolonged hyperglycemia disrupts metabolic homeostasis and leads to acute and chronic complications.Acute ComplicationsAcute complications result from sudden metabolic imbalance.Diabetic ketoacidosis (DKA) mainly appears in type 1 diabetes but may also develop in type 2 diabetes, particularly under extreme stress. It arises from severe insulin deficiency,...
Type II Diabetes Mellitus III: Clinical Manifestations and Diagnosis
Type 2 diabetes mellitus develops gradually and is often asymptomatic in early stages.Clinical ManifestationsWhen symptoms appear, they include fatigue, blurred vision, pruritus, delayed wound healing, and recurrent infections, particularly candidal infections. Peripheral neuropathy may present as numbness or tingling in the extremities. Classic hyperglycemia symptoms—polyuria, polydipsia, and polyphagia—are less common. Most patients are overweight and frequently have associated hypertension...
Type I Diabetes III: Clinical Manifestations
Type 1 diabetes mellitus typically presents with rapid-onset symptoms due to the body’s inability to utilize glucose in the absence of insulin. Since insulin is required for glucose uptake into cells, its deficiency leads to hyperglycemia and cellular energy deprivation, resulting in characteristic clinical features.Polyuria and PolydipsiaOne of the earliest, most prominent symptoms is polyuria (excessive urination). When blood glucose concentrations rise above the renal threshold, the kidneys...